Detection value of glycosylated hemoglobin in the diagnosis of diabetic microangiopathy

Bo Yue; Danjie Li; Xiaoqiang Wei

Detection value of glycosylated hemoglobin in the diagnosis of diabetic microangiopathy

Am J Blood Res. 2020 Oct 15;10(5):252-256. eCollection 2020.

Authors

Bo Yue¹, Danjie Li¹, Xiaoqiang Wei²

Affiliations

¹ Department of Clinical Laboratory, Changhai Hospital, Naval Medical University Shanghai, China.
² Department of Blood Transfusion, Changhai Hospital, Naval Medical University Shanghai, China.

PMID: 33224569
PMCID: PMC7675130

Abstract

Objective: To analyze the detection value of glycosylated hemoglobin (HbA1c) in the diagnosis of diabetic microangiopathy.

Methods: A total of 45 diabetic patients with microangiopathy treated in our hospital from January 2017 to December 2017 were enrolled in the study group, and 45 diabetic patients without microangiopathy in the same period were enrolled in the control group. The levels of HbA1c, fasting blood glucose, D-dimer and antithrombin III (AT-III) of patients were compared between the two groups.

Results: Compared with the control group, the study group had significantly higher fasting blood glucose (7.42±0.54 mmol/L vs. 11.36±0.83 mmol/L) and glycosylated hemoglobin (7.62±0.32% vs. 10.65±0.72), but significantly lower D-dimer (842.96±195.74 μg/L vs. 511.36±110.25 μg/L) and AT-III levels (73.52±23.69% vs. 73.52±23.69%; all P<0.05).

Conclusion: Glycosylated hemoglobin level can not only clearly show the specific conditions of microangiopathy, but also help to diagnose, prevent and treat diabetic microangiopathy, which is worthy of promotion in clinic.

Keywords: D-two dimer; Glycosylated hemoglobin; diabetic microangiopathy; hypersensitivity C-response protein.