Human calcitonin gene-related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells

Br J Pharmacol. 1987 Dec;92(4):695-701. doi: 10.1111/j.1476-5381.1987.tb11373.x.


1 Endothelial cells of human umbilical vein were isolated and cultured in vitro. 2 In these cells there was a concentration-dependent release of prostacyclin and activation of adenylate cyclase by human calcitonin gene-related peptide (hCGRP). The concentration of hCGRP for half-maximum activation of adenylate cyclase (Kact) by hCGRP was 190 nM. 3 Bradykinin induced a ten fold greater release of prostacyclin than CGRP, but did not activate adenylate cyclase. 4 hCGRP may exert its potent vasodilator properties by stimulating release of vasorelaxant substances, including prostacyclin from endothelial cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 6-Ketoprostaglandin F1 alpha / metabolism
  • Adenylyl Cyclases / metabolism*
  • Calcitonin Gene-Related Peptide
  • Endothelium / cytology
  • Endothelium / metabolism
  • Enzyme Activation / drug effects
  • Epoprostenol / metabolism*
  • Female
  • Humans
  • In Vitro Techniques
  • Muscle, Smooth, Vascular / metabolism*
  • Neuropeptides / pharmacology*
  • Umbilical Veins / metabolism
  • Vasodilator Agents / pharmacology*


  • Neuropeptides
  • Vasodilator Agents
  • 6-Ketoprostaglandin F1 alpha
  • Epoprostenol
  • Adenylyl Cyclases
  • Calcitonin Gene-Related Peptide