Long-term Amelioration of OCD Symptoms in a Patient with Chronic Consumption of Psilocybin-containing Mushrooms

J Psychoactive Drugs. 2021 Apr-Jun;53(2):146-148. doi: 10.1080/02791072.2020.1849879. Epub 2020 Nov 22.


Obsessive Compulsive Disorder (OCD) is a chronic neuropsychiatric condition, characterized by obsessions and compulsions, which is usually disabling for the suffering individual. The first-line treatment is not effective in all patients. There is evidence showing the effectiveness of psilocybin and psilocybin-containing mushrooms in the treatment of OCD symptoms. We present the case of a male adult with OCD who showed a clinically meaningful reduction of his OCD symptomatology after the consumption of psilocybin-containing mushrooms. Future research will determine if psilocybin and other psychoactive compounds of psilocybin-containing mushrooms are effective and safe for the treatment of OCD.

Keywords: 5-HT; obsessive compulsive disorder; psilocybin; psychedelic mushrooms.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Agaricales*
  • Humans
  • Male
  • Obsessive-Compulsive Disorder* / drug therapy
  • Psilocybin / adverse effects


  • Psilocybin