"Cancer risk after breast proton therapy considering physiological and radiobiological uncertainties" by Raptis et al. (Physica Medica 76 (2020) 1-6)

Phys Med. 2020 Dec;80:274-276. doi: 10.1016/j.ejmp.2020.11.008. Epub 2020 Nov 20.


The paper by Raptis et al. concludes that proton therapy has an advantage over photon therapy with respect to the induction of a second cancer. Furthermore, the authors conclude that physiological movements and radiobiological parameters do not affect the general trend of lower risk associated with proton therapy. The work is based on a modeling framework which is different from most previously used models on the same subject. This invited commentary puts the findings of the paper in context with other published modeling studies on second cancer risk after proton and photon radiation therapy for breast cancer.

Keywords: Breast cancer; Proton therapy; Second cancer.

Publication types

  • Letter

MeSH terms

  • Breast
  • Breast Neoplasms* / radiotherapy
  • Humans
  • Neoplasms, Second Primary*
  • Proton Therapy* / adverse effects
  • Protons


  • Protons