Polyphenol Extract from Evening Primrose ( Oenothera paradoxa) Inhibits Invasion Properties of Human Malignant Pleural Mesothelioma Cells

Biomolecules. 2020 Nov 19;10(11):1574. doi: 10.3390/biom10111574.


Extracts from the defatted evening primrose (Oenothera paradoxa Hudziok) seeds are the source of a range of stable polyphenolic compounds, including ellagic acid, gallic acid, and catechin. Our studies evaluate, for the first time, the influence of evening primrose isopropanol extract (EPE) on malignant pleural mesothelioma (MPM) cells. MPM is rarely diagnosed, its high aggressiveness and frequently noted chemoresistance limit its treatment schemes and it is characterized by low prognostic features. Here, we demonstrate that EPE inhibited MPM growth in a dose-dependent manner in cells with increased invasion properties. Moreover, EPE treatment resulted in cell cycle arrest in the G2/M phase and increased apoptosis in invasive MPM cell lines. Additionally, EPE strongly limited invasion and MMP-7 secretion in MPM cancer cells. Our original data provide evidence about the potential anti-invasive effects of EPE in MPM therapy treatment.

Keywords: Oenothera paradoxa Hudziok extract; cytotoxicity; evening primrose extract; invasion; malignant pleural mesothelioma; polyphenols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cell Survival / physiology
  • Dose-Response Relationship, Drug
  • Humans
  • Mesothelioma, Malignant / drug therapy
  • Mesothelioma, Malignant / pathology*
  • Neoplasm Invasiveness / pathology
  • Oenothera biennis*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Pleura / drug effects*
  • Pleura / pathology*
  • Polyphenols / isolation & purification
  • Polyphenols / pharmacology*
  • Polyphenols / therapeutic use
  • Seeds


  • Plant Extracts
  • Polyphenols