Pulmonary Manifestations of Skin Disorders in Children

Pediatr Clin North Am. 2021 Feb;68(1):261-276. doi: 10.1016/j.pcl.2020.09.009.


Systemic diseases often manifest with cutaneous findings. Many pediatric conditions with prominent skin findings also have significant pulmonary manifestations. These conditions include both inherited multisystem genetic disorders such as yellow-nail syndrome, neurofibromatosis type 1, tuberous sclerosis complex, hereditary hemorrhagic telangiectasia, Klippel-Trénaunay-Weber syndrome, cutis laxa, Ehlers-Danlos syndrome, dyskeratosis congenita, reactive processes such as mastocytosis, and aquagenic wrinkling of the palms. This overview discusses the pulmonary manifestations of skin disorders.

Keywords: Cutaneous; Genetic; Pulmonary; Systemic.

Publication types

  • Review

MeSH terms

  • Child
  • Humans
  • Lung Diseases / congenital
  • Lung Diseases / etiology*
  • Lung Diseases / genetics
  • Prognosis
  • Skin Diseases / complications*
  • Skin Diseases / congenital
  • Skin Diseases / genetics