A Remarkable Elevation in the Procalcitonin Levels Due to Diabetic Ketoacidosis in a Hemodialysis Patient

Intern Med. 2021 Apr 15;60(8):1231-1235. doi: 10.2169/internalmedicine.5841-20. Epub 2020 Nov 23.

Abstract

Procalcitonin (PCT), a marker of the inflammatory response during infections, can be elevated by diabetic ketoacidosis (DKA). A male patient in his 50s with diabetic nephropathy on hemodialysis presented with vomiting and a reduced level of consciousness and was diagnosed with DKA. His PCT level was markedly elevated, but bacterial cultures (blood, urine, and stool) were negative. The PCT level decreased after DKA improvement. In this patient, DKA probably enhanced the PCT levels. As DKA can increase the PCT levels, an elevation of the PCT levels in DKA patients may not be indicative of infectious diseases, and non-infectious causes of DKA should therefore be considered.

Keywords: diabetic ketoacidosis; hemodialysis; procalcitonin.

MeSH terms

  • Biomarkers
  • Diabetic Ketoacidosis* / complications
  • Diabetic Ketoacidosis* / diagnosis
  • Humans
  • Male
  • Procalcitonin*
  • Renal Dialysis

Substances

  • Biomarkers
  • Procalcitonin