Induction of the SOS response by new 4-quinolones

J Antimicrob Chemother. 1987 Nov;20(5):631-8. doi: 10.1093/jac/20.5.631.

Abstract

The 4-quinolones ciprofloxacin, difloxacin, enoxacin, norfloxacin, ofloxacin, and nalidixic acid were found to induce the SOS response in qualitative and quantitative tests on Escherichia coli K12 containing the sfiA::lacZ gene fusion. Maximum induction of the SOS-response was observed with the quinolone concentrations that produced the most killing. There was also a modest increase in the rate of mutation in the lactose and galactose operons in a GalE- background, provided there was a functioning SOS system.

MeSH terms

  • DNA Repair / drug effects*
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Microbial Sensitivity Tests
  • Mutagens
  • Quinolines / pharmacology*
  • SOS Response, Genetics / drug effects*

Substances

  • Mutagens
  • Quinolines