Addicted to Acidic Microenvironment

Tsunaki Hongu; Thordur Oskarsson

doi:10.1016/j.devcel.2020.11.004

Addicted to Acidic Microenvironment

Dev Cell. 2020 Nov 23;55(4):381-382. doi: 10.1016/j.devcel.2020.11.004.

Authors

Tsunaki Hongu¹, Thordur Oskarsson²

Affiliations

¹ Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
² Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address: t.oskarsson@dkfz.de.

PMID: 33232671
DOI: 10.1016/j.devcel.2020.11.004

Abstract

Acidic pH levels are often observed in growing tumors, with profound effects on cancer cells and surrounding microenvironment. In this issue of Developmental Cell, Funato et al. (2020) show that expression of oncogenic phosphatase of regenerating liver 3 (PRL3) shifts cellular preference for environmental pH, leading to acid addiction.

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MeSH terms

Exocytosis
Humans
Lysosomes
Neoplasm Proteins
Neoplasms*
Protein Tyrosine Phosphatases*
Tumor Microenvironment

Substances

Neoplasm Proteins
Protein Tyrosine Phosphatases