Mortality Patterns Among Industrial Workers Exposed to Chloroprene and Other Substances: Extended Follow-Up

J Occup Environ Med. 2021 Feb 1;63(2):126-138. doi: 10.1097/JOM.0000000000002093.


Objectives: To update the U.S. portion of an historical cohort mortality study of workers with potential exposure to chloroprene (CD) and vinyl chloride (VC) with focus on lung and liver cancer.

Methods: Subjects were 6864 workers from two sites with vital status determined through 2017 for 99% of subjects and cause of death for 97.2% of deaths. Historical exposures to CD and VC were estimated quantitatively. We performed external and internal mortality comparisons.

Results: External comparisons revealed mostly deficits in deaths; internal comparisons revealed no consistent evidence of exposure-response relationships with CD or VC.

Conclusions: Our update continues to support the conclusion that the risk of death from lung or liver cancer is unrelated to exposure to CD or VC at levels experienced by workers in the two U.S. sites.

MeSH terms

  • Cause of Death
  • Chloroprene* / toxicity
  • Cohort Studies
  • Follow-Up Studies
  • Humans
  • Occupational Diseases* / chemically induced
  • Occupational Exposure* / statistics & numerical data
  • Vinyl Chloride* / toxicity


  • Chloroprene
  • Vinyl Chloride