CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence

Harry E Taylor; Clovis S Palmer

doi:10.20900/immunometab20200005

CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence

Immunometabolism. 2020;2(1):e200005. doi: 10.20900/immunometab20200005. Epub 2020 Jan 10.

Authors

Harry E Taylor¹, Clovis S Palmer^{2

3}

Affiliations

¹ Department of Microbiology & Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
² Life Sciences, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, VIC 3004, Australia.
³ Department of Infectious Diseases, Monash University, Melbourne, VIC 3004, Australia.

Abstract

HIV infection is characterized by elevated glycolytic metabolism in CD4 T cells. In their recent study, Valle-Casuso et al. demonstrated that both increased glucose utilization and glutamine metabolism are essential for HIV infectivity and replication in CD4 T cells. Here, we discuss the broader implications of immunometabolism in studies of HIV persistence and their potential to inform new treatment and curative strategies.

Keywords: CD4 T cells; HIV; HIV cure; immune activation; immunometabolism; metabolism.

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