The genetic architecture of sporadic and multiple consecutive miscarriage

Nat Commun. 2020 Nov 25;11(1):5980. doi: 10.1038/s41467-020-19742-5.

Abstract

Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic miscarriage, 750 cases of European ancestry for multiple (≥3) consecutive miscarriage, and up to 359,469 female controls. We identify one genome-wide significant association (rs146350366, minor allele frequency (MAF) 1.2%, P = 3.2 × 10-8, odds ratio (OR) = 1.4) for sporadic miscarriage in our European ancestry meta-analysis and three genome-wide significant associations for multiple consecutive miscarriage (rs7859844, MAF = 6.4%, P = 1.3 × 10-8, OR = 1.7; rs143445068, MAF = 0.8%, P = 5.2 × 10-9, OR = 3.4; rs183453668, MAF = 0.5%, P = 2.8 × 10-8, OR = 3.8). We further investigate the genetic architecture of miscarriage with biobank-scale Mendelian randomization, heritability, and genetic correlation analyses. Our results show that miscarriage etiopathogenesis is partly driven by genetic variation potentially related to placental biology, and illustrate the utility of large-scale biobank data for understanding this pregnancy complication.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Habitual / epidemiology
  • Abortion, Habitual / genetics*
  • Abortion, Habitual / physiopathology
  • Abortion, Spontaneous / epidemiology
  • Abortion, Spontaneous / genetics*
  • Abortion, Spontaneous / physiopathology
  • Adult
  • Aged
  • Case-Control Studies
  • Datasets as Topic
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Humans
  • Inheritance Patterns
  • Medical History Taking
  • Middle Aged
  • Placenta / physiopathology*
  • Polymorphism, Single Nucleotide
  • Pregnancy
  • White People / genetics
  • Young Adult

Grant support