WNT: an unexpected tumor suppressor in medulloblastoma

Branavan Manoranjan; Ashley A Adile; Chitra Venugopal; Sheila K Singh

doi:10.1080/23723556.2020.1834903

WNT: an unexpected tumor suppressor in medulloblastoma

Mol Cell Oncol. 2020 Oct 25;7(6):1834903. doi: 10.1080/23723556.2020.1834903. eCollection 2020.

Authors

Branavan Manoranjan¹, Ashley A Adile², Chitra Venugopal³, Sheila K Singh^{2

3}

Affiliations

¹ Section of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
² Departments of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
³ Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Abstract

Medulloblastoma (MB) represents the most common malignant pediatric brain tumor and is defined by four molecular subgroups with WNT MB having the most favorable prognosis. Our work provides a rational therapeutic option in which the protective effects of WNT-driven MBs may be augmented in Group 3 and 4 MB.

Keywords: Medulloblastoma; WNT; beta-catenin; brain tumor-initiating cell.