Contribution of Rs780094 and Rs1260326 Polymorphisms in GCKR Gene to Non-alcoholic Fatty Liver Disease: A Meta-Analysis Involving 26,552 Participants

Endocr Metab Immune Disord Drug Targets. 2021;21(9):1696-1708. doi: 10.2174/1871530320999201126202706.


Background: Many published studies attempted to elucidate the implication of glucokinase regulator gene (GCKR) polymorphisms in the susceptibility to non-alcoholic fatty liver disease (NAFLD), but the results among them were still controversial.

Objective: This meta-analysis aims to precisely assess the relationship between the GCKR polymorphisms and the risk of NAFLD.

Methods: Systematic computerized searches in six databases were performed and updated on April 6, 2020. Meta-analyses were conducted by calling the R programs based on accumulated epidemiological data. Odds ratio (OR) and 95% confidential interval (CI) were calculated to summarize the effect estimates.

Results: In total, 25 studies including 6,598 cases and 19,954 controls were included. The pooled estimates indicated that the T allele carrier of the GCKR rs780094 polymorphism has predisposition to NAFLD (allele model: OR: 1.20, 95% CI: 1.11~1.29; homozygote model: OR: 1.38, 95% CI: 1.15~1.67; heterozygote model: OR: 1.25, 95% CI: 1.12~1.39; dominant model: OR: 1.29, 95% CI: 1.13~1.47; recessive model: OR: 1.18, 95% CI: 1.06~1.31), and the same as the rs1260326 polymorphism (allele model: OR: 1.32, 95% CI: 1.22~1.42; homozygote model: OR: 1.65, 95% CI: 1.40~1.94; heterozygote model: OR: 1.24, 95% CI: 1.07~1.43; dominant model: OR: 1.39, 95% CI: 1.21~1.59; recessive model: OR: 1.44, 95% CI: 1.28~1.62). Further stratified analyses according to age and ethnicity confirmed the statistical existence in most subgroups.

Conclusion: This meta-analysis suggested that both of the GCKR rs780094 and rs1260326 polymorphisms are significantly associated with the increased risk of NAFLD.

Keywords: Non-alcoholic fatty liver disease; glucokinase regulator gene; meta-analysis; rs1260326; rs780094; susceptibility..

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics*
  • Case-Control Studies
  • Gene Frequency
  • Genetic Association Studies / statistics & numerical data
  • Genetic Predisposition to Disease
  • Humans
  • Non-alcoholic Fatty Liver Disease / epidemiology
  • Non-alcoholic Fatty Liver Disease / genetics*
  • Polymorphism, Single Nucleotide
  • Risk Factors


  • Adaptor Proteins, Signal Transducing
  • GCKR protein, human