Outlines of the Japanese guidelines for the management of primary cutaneous lymphomas 2020

J Dermatol. 2021 Feb;48(2):e49-e71. doi: 10.1111/1346-8138.15707. Epub 2020 Nov 27.


Since the publication of the Japanese "Guidelines for the management of cutaneous lymphomas" in 2011, the World Health Organization (WHO) classification of hematolymphoid neoplasms and the WHO-European Organisation for Research and Treatment of Cancer classification for primary cutaneous lymphomas were updated and a number of novel systemic drugs for cutaneous T-cell lymphoma had been approved in Japan. In 2020, we revised the Japanese guidelines for the management of cutaneous lymphomas with consideration of the recent advances in the understanding of the pathophysiology and classification of cutaneous lymphomas together with the update of treatment strategies reflecting the advent of novel drugs. In addition to a brief explanation of epidemiology, diagnosis, staging system, prognosis and management of each subtype of cutaneous lymphomas, the recommendations for nine clinical questions regarding treatment options that can vary even among experts are also described. A systematic review process and determination of recommendations in answer to each clinical question have been performed in accordance with the Grading of Recommendations, Assessment, Development and Evaluation scheme by a multidisciplinary expert panel consisting of dermatologists, a hematologist and a radiation oncologist. In this article, we present the outlines of the revised Japanese "Guidelines for the management of cutaneous lymphomas".

Keywords: GRADE system; cutaneous lymphomas; guidelines; skin-directed therapies; systemic therapies.

Publication types

  • Systematic Review

MeSH terms

  • Humans
  • Japan / epidemiology
  • Lymphoma, B-Cell*
  • Lymphoma, Non-Hodgkin*
  • Lymphoma, T-Cell, Cutaneous* / diagnosis
  • Lymphoma, T-Cell, Cutaneous* / epidemiology
  • Lymphoma, T-Cell, Cutaneous* / therapy
  • Skin Neoplasms* / diagnosis
  • Skin Neoplasms* / epidemiology
  • Skin Neoplasms* / therapy