Antimicrobial enzymatic biofuel cells

Chem Commun (Camb). 2020 Dec 25;56(99):15589-15592. doi: 10.1039/d0cc07472a. Epub 2020 Nov 27.

Abstract

A compact antibiotic delivery system based on enzymatic biofuel cells was prepared, in which ampicillin was released when discharged in the presence of glucose and O2. The release of ampicillin was effective in inhibiting the growth of bacterium Escherichia coli as confirmed by ex situ and in situ release studies in culture media.

MeSH terms

  • Ampicillin / chemistry
  • Ampicillin / metabolism
  • Ampicillin / pharmacology*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology*
  • Bioelectric Energy Sources*
  • Escherichia coli / drug effects*
  • Escherichia coli / growth & development
  • Glucose / metabolism
  • Oxygen / metabolism

Substances

  • Anti-Bacterial Agents
  • Ampicillin
  • Glucose
  • Oxygen