Novel Hepatitic C Virus (HCV) Diagnosis and Treatment Delivery Systems: Facilitating HCV Elimination by Thinking Outside the Clinic

Sahar Bajis; Tanya L Applegate; Jason Grebely; Gail V Matthews; Gregory J Dore

doi:10.1093/infdis/jiaa366

Novel Hepatitic C Virus (HCV) Diagnosis and Treatment Delivery Systems: Facilitating HCV Elimination by Thinking Outside the Clinic

J Infect Dis. 2020 Nov 27;222(Suppl 9):S758-S772. doi: 10.1093/infdis/jiaa366.

Authors

Sahar Bajis¹, Tanya L Applegate¹, Jason Grebely¹, Gail V Matthews¹, Gregory J Dore¹

Affiliation

¹ The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.

PMID: 33245354
DOI: 10.1093/infdis/jiaa366

Abstract

The World Health Organization has set a goal to eliminate hepatitis C virus (HCV) infection as public health threat by 2030. Although the advent of highly effective and tolerable direct-acting antiviral therapy has paved the way for HCV elimination, most people with HCV infection remain undiagnosed and untreated globally, with striking disparities between high-income and low- to middle-income countries. Novel decentralized and cost-effective "test-and-treat" strategies are critically needed to identify the millions of people unaware of their status and link them to treatment.

Keywords: HCV; HCV elimination; direct-acting antivirals; global health; testing strategies.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Algorithms
Antiviral Agents / therapeutic use*
Disease Eradication / organization & administration*
Hepacivirus / isolation & purification
Hepatitis C / diagnosis*
Hepatitis C / drug therapy*
Humans
Point-of-Care Testing
Socioeconomic Factors
World Health Organization

Substances

Antiviral Agents