Novel Hepatitic C Virus (HCV) Diagnosis and Treatment Delivery Systems: Facilitating HCV Elimination by Thinking Outside the Clinic

J Infect Dis. 2020 Nov 27;222(Suppl 9):S758-S772. doi: 10.1093/infdis/jiaa366.


The World Health Organization has set a goal to eliminate hepatitis C virus (HCV) infection as public health threat by 2030. Although the advent of highly effective and tolerable direct-acting antiviral therapy has paved the way for HCV elimination, most people with HCV infection remain undiagnosed and untreated globally, with striking disparities between high-income and low- to middle-income countries. Novel decentralized and cost-effective "test-and-treat" strategies are critically needed to identify the millions of people unaware of their status and link them to treatment.

Keywords: HCV; HCV elimination; direct-acting antivirals; global health; testing strategies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Algorithms
  • Antiviral Agents / therapeutic use*
  • Disease Eradication / organization & administration*
  • Hepacivirus / isolation & purification
  • Hepatitis C / diagnosis*
  • Hepatitis C / drug therapy*
  • Humans
  • Point-of-Care Testing
  • Socioeconomic Factors
  • World Health Organization


  • Antiviral Agents