On multistep tumor growth models of fractional variable-order

Abstract

Fractional mathematical oncology is a research topic that applies non-integer order calculus to tackle cancer problems such as tumor growth analysis or its optimal treatment. This work proposes a multistep exponential model with a fractional variable-order representing the evolution history of a tumor. Model parameters are tuned according to variable fractional order profiles while assessing their capability of fitting a clinical time series. The results point to the superiority of the proposed model in describing the experimental data, thus providing new perspectives for modeling tumor growth.

Keywords: Cancer; Fractional calculus; Mathematical oncology; ODE.