Echotexture Analysis of Prostate Parenchyma for Detection of Benign Prostatic Hyperplasia in Dogs

Top Companion Anim Med. 2021 Mar:42:100501. doi: 10.1016/j.tcam.2020.100501. Epub 2020 Nov 26.

Abstract

Ultrasonography is one of the most common methods for the diagnosis of prostate disorders, such as benign prostatic hyperplasia (BPH), in dogs. Changes in the echotexture are one of the indicators used to diagnose prostate disorders. The purpose of this study was to investigate the changes occurred in the dogs' prostate echotexture during the induction of BPH using image analysis. Twenty sexually mature male intact mixed-breed dogs were selected and divided randomly into control and BPH-induced groups. BPH was induced using testosterone and estrogen injections for 63 days. The ultrasound imaging of the dogs' prostate was performed during the induction of BPH on days 0, 21, 42, and 63. The echotexture of the prostate parenchyma was analyzed using the Image J software. Then, the changes in the echotexture and its correlation and linear regression with the prostate volume and canine prostate specific esterase (CPSE) concentration were evaluated by statistical tests. The prostate parenchyma echotexture did not show any significant changes during the induction of BPH and in comparison with that of the control group. While prostate volume and CPSE concentration increased significantly, indicating that BPH was induced in the dogs. There was no significant correlation and linear regression between the prostate echotexture and prostate volume or between the CPSE concentration and prostate echotexture. According to the results, the alteration in the prostate parenchymal echotexture did not occur in the early stages of induced BPH, but significant changes occurred in the prostate volume and CPSE concentration during those early stages.

Keywords: benign prostatic hyperplasia; canine prostate specific esterase; echotexture; ultrasonography.

Publication types

  • Randomized Controlled Trial, Veterinary

MeSH terms

  • Animals
  • Biomarkers / blood
  • Dog Diseases / enzymology
  • Dog Diseases / pathology*
  • Dogs
  • Esterases / blood*
  • Male
  • Organ Size
  • Prostate / enzymology*
  • Prostatic Hyperplasia / diagnostic imaging*
  • Prostatic Hyperplasia / pathology
  • Prostatic Hyperplasia / veterinary
  • Ultrasonography / methods*
  • Ultrasonography / veterinary

Substances

  • Biomarkers
  • Esterases