Energy-dependent efflux mediated by class L (tetL) tetracycline resistance determinant from streptococci

Antimicrob Agents Chemother. 1987 Oct;31(10):1648-50. doi: 10.1128/AAC.31.10.1648.

Abstract

The class L (TetL) tetracycline resistance determinant from streptococci specified resistance and an energy-dependent decreased accumulation of tetracycline in both Streptococcus faecalis and Escherichia coli. Using E. coli, we showed that the reduced uptake resulted from active efflux. The streptococcal class M determinant, known to render the protein synthesis machinery of S. faecalis resistant to tetracycline inhibition, did not alter tetracycline transport in either host.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Energy Metabolism / drug effects*
  • Escherichia coli / drug effects
  • Streptococcus / drug effects*
  • Tetracycline Resistance
  • Tetracyclines / pharmacology*

Substances

  • Tetracyclines