Hypervirulent Klebsiella pneumoniae infection in a woman with a CDH1 gene mutation

Alexander J Kaye; Adam T Chin; Michelle C Liang; Roberto Viau Colindres

doi:10.1016/j.idcr.2020.e01000

Hypervirulent Klebsiella pneumoniae infection in a woman with a CDH1 gene mutation

IDCases. 2020 Nov 4:23:e01000. doi: 10.1016/j.idcr.2020.e01000. eCollection 2021.

Authors

Alexander J Kaye¹, Adam T Chin², Michelle C Liang², Roberto Viau Colindres³

Affiliations

¹ Tufts University School of Medicine, Boston, MA, USA.
² New England Eye Center, Tufts Medical Center, Boston, MA, USA.
³ Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, USA.

Abstract

The CDH1 gene, which encodes E-cadherin, may be associated with cancer when mutated, but the significance of mutations in the context of infection is unknown. In this report, we describe a case of disseminated hypervirulent Klebsiella pneumoniae infection in a 49 year old Caucasian woman with a documented CDH1 mutation.

Keywords: Cadherin-1; Disease susceptibility; Host-pathogen interactions; Klebsiella pneumoniae/pathogenicity; Suppurative; Uveitis.

Publication types

Case Reports