Effects of Lipid-Based Encapsulation on the Bioaccessibility and Bioavailability of Phenolic Compounds

Molecules. 2020 Nov 26;25(23):5545. doi: 10.3390/molecules25235545.


Phenolic compounds (quercetin, rutin, cyanidin, tangeretin, hesperetin, curcumin, resveratrol, etc.) are known to have health-promoting effects and they are accepted as one of the main proposed nutraceutical group. However, their application is limited owing to the problems related with their stability and water solubility as well as their low bioaccessibility and bioavailability. These limitations can be overcome by encapsulating phenolic compounds by physical, physicochemical and chemical encapsulation techniques. This review focuses on the effects of encapsulation, especially lipid-based techniques (emulsion/nanoemulsion, solid lipid nanoparticles, liposomes/nanoliposomes, etc.), on the digestibility characteristics of phenolic compounds in terms of bioaccessibility and bioavailability.

Keywords: PMF; bioaccessibility; bioavailability; curcumin; encapsulation; lipid-based delivery systems; polyphenols; resveratrol.

Publication types

  • Review

MeSH terms

  • Biological Availability
  • Drug Carriers / chemistry*
  • Drug Compounding*
  • Drug Delivery Systems*
  • Humans
  • Lipids / chemistry*
  • Molecular Structure
  • Phenols / chemistry*
  • Phenols / pharmacokinetics*
  • Polyphenols / chemistry
  • Tissue Distribution


  • Drug Carriers
  • Lipids
  • Phenols
  • Polyphenols