Mucuna pruriens Administration Minimizes Neuroinflammation and Shows Anxiolytic, Antidepressant and Slimming Effects in Obese Rats

Molecules. 2020 Nov 26;25(23):5559. doi: 10.3390/molecules25235559.


This study evaluated the effect of Mucuna pruriens (MP) administration on neuroinflammation and behavioral and murinometric parameters in obese rats. Proximate composition, oligosaccharide and phenolic compound profile of MP were determined. Wistar adult male rats were randomized into healthy (HG) and obese group (OG). The HG consumed a control chow diet while OG consumed a cafeteria diet for eight weeks. Then, they were subdivided into: Healthy (HG); Healthy with MP administration (HGMP); Obese (OG); Obese with MP administration (OGMP), with the consumption of the respective diets remaining for another eight weeks, in addition to gavage with MP extract to supplemented groups (750 mg/kg weight). MP presented a composition rich in proteins and phenolic compounds, especially catechin, in addition to 1-kestose and levodopa. Supplementation reduced food intake, body weight, and thoracic and abdominal circumferences in obese rats. MP showed anxiolytic and antidepressant effects and reduced morphological damage and expression of interleukin 6 in the hippocampus of obese rats. MP treatment showed satietogenic, slimming, anxiolytic and antidepressant effects, besides to minimizing hippocampal neuroinflammation in obese rats. Our results demonstrated the potential anti-obesity of MP which are probably related to the high content of bioactive compounds present in this plant extract.

Keywords: bioactive compounds; cafeteria diet; interleukin 6; neurobehavior; obesity; weigh loss.

MeSH terms

  • Animals
  • Anti-Anxiety Agents / administration & dosage
  • Anti-Anxiety Agents / chemistry
  • Anti-Anxiety Agents / pharmacology*
  • Antidepressive Agents / administration & dosage
  • Antidepressive Agents / chemistry*
  • Antidepressive Agents / pharmacology*
  • Behavior, Animal / drug effects
  • Disease Models, Animal
  • Histocytochemistry
  • Immunohistochemistry / methods
  • Mucuna / chemistry*
  • Obesity
  • Phytochemicals / chemistry
  • Phytochemicals / pharmacology
  • Phytotherapy
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Rats


  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Phytochemicals
  • Plant Extracts