Extracellular iron chelation in Cryptococcus neoformans

J Med Vet Mycol. 1987 Dec;25(6):415-8.

Abstract

Low-iron minimal medium supported growth of Cryptococcus neoformans but spent medium contained no hydroxamates, organic acids or other iron chelators. Exogenous deferoxamine stimulated growth in extreme iron-limitation, while neither organic acids nor quartersaturated transferrins were stimulatory. These results suggest two iron uptake mechanisms, one dependent upon exogenous hydroxamate, the other hydroxamate-independent.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cryptococcus / metabolism*
  • Cryptococcus neoformans / growth & development
  • Cryptococcus neoformans / metabolism*
  • Culture Media
  • Hydrogen-Ion Concentration
  • Iron Chelating Agents / metabolism*

Substances

  • Culture Media
  • Iron Chelating Agents