The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway

Patricia Hermand; Slim Azouzi; Emilie-Fleur Gautier; François Guillonneau; Vincent Bondet; Darragh Duffy; Sebastien Dechavanne; Pierre-Louis Tharaux; Patrick Mayeux; Caroline Le Van Kim; Berengere Koehl

doi:10.3324/haematol.2019.238295

The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway

Haematologica. 2020 Dec 1;105(12):2851-2854. doi: 10.3324/haematol.2019.238295.

Affiliations

¹ Université de Paris, Institut National de la Transfusion Sanguine, Paris, France.
² Institut national de la transfusion sanguine and Laboratoire Excellence GR-Ex, Paris, France.
³ Université de Paris, INSERM U1016, Institut Cochin, Paris, France.
⁴ Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France.
⁵ Université de Paris, Paris Cardiovascular Centre, Paris, France.
⁶ Sickle Cell Disease Center, Hematology Unit, Hôpital Robert Debré, Paris, France.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Anemia, Sickle Cell*
Humans
Interferon-alpha
Neutrophils*
Proteome
Signal Transduction

Substances

Interferon-alpha
Proteome

Grants and funding

Funding: We thank the patients and their families for their participation in the study and all members of the Sickle Cell Disease Center from the Robert Debré Hospital for the management of blood samples. This work was supported by a grant from l’Association Recherche et Transfusion, the Institut National de la Transfusion Sanguine, and the Laboratory of Excellence GR-Ex, reference ANR-11-LABX-0051; GR-Ex is funded by the program “Investissements d’avenir” of the French National Research Agency, reference ANR-11-IDEX-0005-02. The Orbitrap Fusion mass spectrometer was acquired with funds from the FEDER through the "Operational Programme for Competitiveness and Employment 2007-2013" and from the "Canceropole Ile de France".