Modelling intestinal inflammation and infection using 'mini-gut' organoids

Nat Rev Gastroenterol Hepatol. 2021 Feb;18(2):89-90. doi: 10.1038/s41575-020-00391-4.

Abstract

In 2020, major advances to the understanding of gastrointestinal inflammatory and infectious disease have been made using ‘mini-gut’ organoids. Key findings include the discovery of somatic inflammatory gene mutations in ulcerative colitis epithelium, a unique mutational signature in colorectal cancer caused by genotoxic Escherichia coli, and infection of intestinal organoids by SARS-CoV-2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19 / genetics
  • Colitis, Ulcerative / genetics*
  • Colitis, Ulcerative / microbiology
  • Colitis, Ulcerative / physiopathology
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / microbiology
  • Colorectal Neoplasms / physiopathology
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / genetics
  • Escherichia coli Infections / physiopathology
  • Humans
  • Infections / genetics*
  • Infections / virology
  • Inflammation / genetics*
  • Inflammation / virology
  • Interleukin-17 / genetics
  • Intestines / physiopathology*
  • Models, Biological
  • Mutation
  • Organoids / physiopathology*
  • SARS-CoV-2 / isolation & purification

Substances

  • IL17F protein, human
  • Interleukin-17