Abstract
In 2020, major advances to the understanding of gastrointestinal inflammatory and infectious disease have been made using ‘mini-gut’ organoids. Key findings include the discovery of somatic inflammatory gene mutations in ulcerative colitis epithelium, a unique mutational signature in colorectal cancer caused by genotoxic Escherichia coli, and infection of intestinal organoids by SARS-CoV-2.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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COVID-19 / genetics
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Colitis, Ulcerative / genetics*
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Colitis, Ulcerative / microbiology
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Colitis, Ulcerative / physiopathology
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Colorectal Neoplasms / genetics*
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Colorectal Neoplasms / microbiology
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Colorectal Neoplasms / physiopathology
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Escherichia coli / isolation & purification
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Escherichia coli Infections / genetics
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Escherichia coli Infections / physiopathology
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Humans
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Infections / genetics*
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Infections / virology
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Inflammation / genetics*
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Inflammation / virology
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Interleukin-17 / genetics
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Intestines / physiopathology*
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Models, Biological
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Mutation
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Organoids / physiopathology*
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SARS-CoV-2 / isolation & purification
Substances
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IL17F protein, human
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Interleukin-17