Potential role of exosome-based allorecognition pathways involved in lung transplant rejection

J Thorac Cardiovasc Surg. 2021 Feb;161(2):e129-e134. doi: 10.1016/j.jtcvs.2020.04.183. Epub 2020 Jun 18.


Innate and adaptive immunity both contribute to allorecognition mechanisms that drive rejection after lung transplantation. Classic allorecognition pathways have been extensively described, but there continues to be several unanswered questions. Exosome research appears to be a novel and potentially significant area of allorecognition research and could be the missing link that answers some existing questions. This article reviews literature that is associated with allorecognition pathways and the role of exosomes in alloreactivity.

Publication types

  • Editorial