Whiplash injury successfully treated with prolotherapy: a case report with long-term follow up

Regen Med. 2020 Sep;15(9):2075-2084. doi: 10.2217/rme-2020-0063. Epub 2020 Dec 1.


Background: Chronic whiplash-associated disorder (WAD) can develop after flexion/extension injuries and may be refractory to standard-of-care therapies. Aim: To present successful treatment of severe, longstanding, treatment resistant WAD with prolotherapy. Materials & methods: Four, monthly sessions of fluoroscopically guided prolotherapy with phenol-glycerin-glucose. Electronic data on pain (visual analog score), disability (Oswestry Disability Index), pain interference, depression, anxiety, sleep and quality of life were collected with University of Washington's (WA, USA) online tool for a total of 21 months. This study conforms to the Case Report Guidelines (CARE). Results: Significant improvement was achieved and maintained through 18 months after treatment in all assessed pain and functional measures. Conclusion: Regenerative medicine, including prolotherapy may be an appropriate treatment option for carefully selected patients with WAD.

Keywords: WAD; headache; neck pain; prolotherapy; regenerative medicine; whiplash-associated disorder.

Publication types

  • Case Reports

MeSH terms

  • Follow-Up Studies
  • Humans
  • Pain
  • Prolotherapy*
  • Quality of Life
  • Whiplash Injuries* / drug therapy