Failure of diterpenes from Jatropha curcas to induce mutation in Salmonella typhimurium TA98 and TA100

W Rojanapo; J Pimbua; T Glinsukon; W Naengchomnong; Y Thebtaranonth

Failure of diterpenes from Jatropha curcas to induce mutation in Salmonella typhimurium TA98 and TA100

Res Commun Chem Pathol Pharmacol. 1987 Dec;58(3):397-400.

Authors

W Rojanapo¹, J Pimbua, T Glinsukon, W Naengchomnong, Y Thebtaranonth

Affiliation

¹ Research Division, National Cancer Institute, Bangkok, Thailand.

PMID: 3326080

Abstract

No mutagenicity of five diterpenes isolated from the roots of Jatropha curcas was detected by Ame's test using both TA98 and TA100 tester strains with or without S-9 fraction from livers of rats treated with polychlorinated biphenyl.

MeSH terms

Animals
Biotransformation
Diterpenes / pharmacokinetics
Diterpenes / toxicity*
In Vitro Techniques
Microsomes, Liver / metabolism
Mutagenicity Tests
Mutagens* / pharmacokinetics
Plants, Medicinal / analysis*
Rats
Salmonella typhimurium / genetics

Substances

Diterpenes
Mutagens