Brucellar meningitis

Rev Infect Dis. Jul-Aug 1987;9(4):810-22. doi: 10.1093/clinids/9.4.810.


Neurobrucellosis develops in less than 5% of cases of systemic brucellosis; however, most patients with neurobrucellosis have meningeal involvement. Seven new cases of brucellar meningitis and 17 cases from the Spanish- and English-language medical literature are analyzed in terms of epidemiologic data, clinical manifestations, laboratory results for cerebrospinal fluid and serum, treatment, and course of the disease. Brucellar meningitis mimics other neurologic and non-neurologic conditions, and its diagnosis is only suggested in the presence of adequate epidemiologic information. Isolation of Brucella from the cerebrospinal fluid is uncommon. Treatment is accomplished with the combination of tetracycline or doxycycline and streptomycin, rifampin, or both. Mean length of therapy in the seven new cases was 8.5 months. Brucellar meningitis has a better prognosis than other forms of chronic meningitis, and mortality is low for reasons that are not clear; however, the incidence of minor sequelae is high.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Brucellosis* / diagnosis
  • Brucellosis* / immunology
  • Brucellosis* / pathology
  • Doxycycline / therapeutic use
  • Female
  • Humans
  • Male
  • Meningitis* / drug therapy
  • Meningitis* / microbiology
  • Middle Aged
  • Prednisone / therapeutic use
  • Rifampin / therapeutic use


  • Doxycycline
  • Prednisone
  • Rifampin