Supportive medication in cancer during pregnancy

BMC Pregnancy Childbirth. 2020 Dec 1;20(1):747. doi: 10.1186/s12884-020-03432-7.


While pregnancy-related malignancies are quite rare, their incidence is increasing and thus affecting more and more women nowadays. Their management, however, with both chemotherapy and supportive agents remains quite challenging and it seems crucial to define the optimal treatment for this special population. Concerning supportive medication, it is clinically significant to determine whether commonly used agents, including Granulocyte Colony-Stimulating Factors, Erythropoiesis-stimulating agents, Bisphosphonates, Anticoagulation agents, Antiemetics and Glucocorticoids are indeed effective in ameliorating chemotherapy side effects. Meanwhile, it is of great importance that the administration of any of these agents is safe for both mother and fetus. This review aims to provide a précis of the current literature regarding both safety and efficacy of all categories of supportive medication during pregnancy.

Keywords: Aanticoagulation agents; Antiemetics; Erythropoiesis-stimulating agents; Ggranulocyte colony-stimulating factors; Glucocorticoids; Ooncology patients; Pregnancy supportive care; bisphosphonates.

Publication types

  • Review

MeSH terms

  • Anticoagulants / therapeutic use
  • Antiemetics / therapeutic use
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects
  • Female
  • Glucocorticoids / therapeutic use
  • Hematinics / therapeutic use
  • Humans
  • Neoplasms / drug therapy*
  • Palliative Care / methods
  • Pregnancy
  • Pregnancy Complications, Neoplastic / drug therapy*


  • Anticoagulants
  • Antiemetics
  • Antineoplastic Agents
  • Glucocorticoids
  • Hematinics