The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices

Haofeng Qiu; Zhangyong Si; Yang Luo; Peipei Feng; Xujin Wu; Wenjia Hou; Yabin Zhu; Mary B Chan-Park; Long Xu; Dongmei Huang

doi:10.3389/fbioe.2020.00910

The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices

Front Bioeng Biotechnol. 2020 Nov 11:8:910. doi: 10.3389/fbioe.2020.00910. eCollection 2020.

Authors

Haofeng Qiu¹, Zhangyong Si², Yang Luo¹, Peipei Feng¹, Xujin Wu¹, Wenjia Hou¹, Yabin Zhu¹, Mary B Chan-Park², Long Xu³, Dongmei Huang⁴

Affiliations

¹ School of Medicine, Ningbo University, Ningbo, China.
² School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore.
³ Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo, China.
⁴ Ningbo Baoting Biotechnology Co., Ltd., Ningbo, China.

Abstract

Medical device contamination caused by microbial pathogens such as bacteria and fungi has posed a severe threat to the patients' health in hospitals. Due to the increasing resistance of pathogens to antibiotics, the efficacy of traditional antibiotics treatment is gradually decreasing for the infection treatment. Therefore, it is urgent to develop new antibacterial drugs to meet clinical or civilian needs. Antibacterial polymers have attracted the interests of researchers due to their unique bactericidal mechanism and excellent antibacterial effect. This article reviews the mechanism and advantages of antimicrobial polymers and the consideration for their translation. Their applications and advances in medical device surface coating were also reviewed. The information will provide a valuable reference to design and develop antibacterial devices that are resistant to pathogenic infections.

Keywords: antibacterial effect; antibacterial polymer; mechanism; medical device; surface coating.

Publication types

Review