A review of the methods of chemical synthesis of sulphate and glucuronide conjugates

Xenobiotica. 1987 Dec;17(12):1451-71. doi: 10.3109/00498258709044005.


1. Methods for the synthesis of drug conjugates with sulphuric acid have been reviewed. 2. Some analytical methods are presented for the analysis of sulphate conjugates. 3. The synthesis of several types of N, O and C beta-D-glucuronides is reviewed. Different beta-coupling reactions of protected glucuronides are presented. 4. Application of n.m.r. and mass spectrometry to the analysis of beta-D-glucuronides is discussed.

Publication types

  • Review

MeSH terms

  • Chemical Phenomena
  • Chemistry
  • Glucuronates / analysis
  • Glucuronates / chemical synthesis*
  • Sulfates / analysis
  • Sulfates / chemical synthesis*


  • Glucuronates
  • Sulfates