Orbital Epstein-Barr virus-related post-transplant lymphoproliferative disorder in a 13-year-old girl with cord blood transplantation

Transpl Infect Dis. 2021 Jun;23(3):e13536. doi: 10.1111/tid.13536. Epub 2020 Dec 18.

Abstract

Epstein-Barr virus-associated post-transplant lymphoproliferative disorder (EBV-PTLD) is increasingly recognized as a life-threatening complication after transplantation. Most areas affected by EBV-PTLD are lymph nodes, with occasional reports of extranodal lesions such as the gastrointestinal tract and central nervous system; however, orbital regions are extremely rare. We report a case of EBV-PTLD in a cord blood transplant recipient with a tumor in the upper right eyelid. Ultimately, eye symptoms were the first signs of PTLD. Transplant physicians should consider the possibility of PTLD when encountering an orbital lesion.

Keywords: Epstein-Barr virus; cord blood transplantation; orbital PTLD; post-transplant lymphoproliferative disorder.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Cord Blood Stem Cell Transplantation*
  • Epstein-Barr Virus Infections*
  • Female
  • Herpesvirus 4, Human
  • Humans
  • Lymphoproliferative Disorders*
  • Transplant Recipients