Effectiveness of almagate in gastroesophageal reflux disease: a post-hoc analysis of a randomized cross-over double-blind study

Rev Esp Enferm Dig. 2021 Jun;113(6):479. doi: 10.17235/reed.2020.7449/2020.


Almagate (aluminium-magnesium hydroxycarbonate hydrate) is a widely used antacid in Spain as an over-the-counter formulation. However, data on the control of acidity in patients with gastroesophageal reflux disease (GERD) are scarce. Herein we report a post-hoc analysis of a randomized crossover double-blind trial (ALR-006; data on file), in which equivalent single oral doses (1.5 g) of two formulations of almagate (AlmaxRetard® and Almax®, Laboratorios Almirall, Barcelona, Spain) were both effective for reflux esophagitis.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aluminum Hydroxide
  • Carbonates
  • Double-Blind Method
  • Gastroesophageal Reflux* / drug therapy
  • Humans
  • Magnesium Hydroxide
  • Magnesium*
  • Spain


  • Carbonates
  • almagate
  • Aluminum Hydroxide
  • Magnesium
  • Magnesium Hydroxide