Leptin and Adiponectin Concentrations Independently Predict Future Accumulation of Visceral Fat in Nondiabetic Japanese Americans

Obesity (Silver Spring). 2021 Jan;29(1):233-239. doi: 10.1002/oby.23035. Epub 2020 Dec 2.


Objective: Whether leptin and adiponectin are independently associated with regional body fat distribution was investigated in a prospective study of Japanese Americans.

Methods: Nondiabetic participants 39 to 79 years of age were followed for 5 years to assess change in body composition. Leptin and adiponectin concentrations were evaluated at baseline and by single-slice computed tomography measurements of intra-abdominal fat (IAF), abdominal subcutaneous fat (SCF), and thigh SCF cross-sectional areas at baseline and at 5 years.

Results: Ninety-six men and ninety-five women without diabetes had the following baseline mean (SD) values: age 45.7 (3.5) years and 46.4 (3.9) years, IAF 78.7 (38.6) cm2 and 62.1 (39.0) cm2 , leptin concentration 4.5 (2.3) μg/L and 10.2 (5.2) μg/L, and adiponectin concentration 7.4 (3.2) μg/mL and 10.8 (4.7) μg/mL, respectively. Baseline leptin (β = 1.7722, P = 0.014) and adiponectin concentrations (β = -0.4162, P < 0.001) were significantly associated with IAF change over 5 years in multivariable models adjusting for age, sex, diabetes family history, weight change over 5 years, and baseline measurements of BMI, IAF, abdominal SCF, waist circumference, thigh fat, and homeostatic model assessment of insulin resistance.

Conclusions: In nondiabetic Japanese Americans, a higher concentration of leptin was associated with greater accumulation of IAF and a higher concentration of adiponectin with lesser accumulation of IAF over 5 years.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood*
  • Adult
  • Asian Americans
  • Body Composition*
  • Body Fat Distribution
  • Diabetes Mellitus
  • Female
  • Humans
  • Insulin Resistance
  • Intra-Abdominal Fat*
  • Japan / ethnology
  • Leptin / blood*
  • Male
  • Middle Aged
  • Prospective Studies
  • Thigh
  • United States / epidemiology


  • Adiponectin
  • Leptin