Degenerative and regenerative processes in amyotrophic lateral sclerosis: motor reserve, adaptation and putative compensatory changes

doi:10.4103/1673-5374.300440

. 2021 Jun;16(6):1208-1209.

doi: 10.4103/1673-5374.300440.

Degenerative and regenerative processes in amyotrophic lateral sclerosis: motor reserve, adaptation and putative compensatory changes

Peter Bede¹, Ulrich Bogdahn², Jasmin Lope³, Kai Ming Chang⁴, Sophia Xirou⁵, Foteini Christidi⁵

Affiliations

¹ Computational Neuroimaging Group, Trinity College Dublin, Dublin, Ireland; Biomedical Imaging Laboratory, Sorbonne University, Paris, France.
² Department of Neurology, University of Regensburg, Regensburg, Germany.
³ Computational Neuroimaging Group, Trinity College Dublin, Dublin, Ireland.
⁴ Electronics and Computer Science, University of Southampton, Southampton, UK.
⁵ First Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.

PMID: 33269779
PMCID: PMC8224145
DOI: 10.4103/1673-5374.300440

Degenerative and regenerative processes in amyotrophic lateral sclerosis: motor reserve, adaptation and putative compensatory changes

Peter Bede et al. Neural Regen Res. 2021 Jun.

. 2021 Jun;16(6):1208-1209.

doi: 10.4103/1673-5374.300440.

Authors

Peter Bede¹, Ulrich Bogdahn², Jasmin Lope³, Kai Ming Chang⁴, Sophia Xirou⁵, Foteini Christidi⁵

Affiliations

¹ Computational Neuroimaging Group, Trinity College Dublin, Dublin, Ireland; Biomedical Imaging Laboratory, Sorbonne University, Paris, France.
² Department of Neurology, University of Regensburg, Regensburg, Germany.
³ Computational Neuroimaging Group, Trinity College Dublin, Dublin, Ireland.
⁴ Electronics and Computer Science, University of Southampton, Southampton, UK.
⁵ First Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.

PMID: 33269779
PMCID: PMC8224145
DOI: 10.4103/1673-5374.300440

No abstract available

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Conflict of interest statement

None

Figures

**Figure 1**
Functional reorganization in ALS based on functional MRI studies. Motor task studies in ALS have consistently captured increased cerebellar, thalamic and basal ganglia signal and an activation shift from the primary motor cortex to premotor, supplementary motor and ipsilateral motor cortices. Cognitive paradigms have also revealed broadened and aberrant activation patterns and resting state studies captured increased cerebro-cerebellar and default mode network connectivity. ALS: Amyotrophic lateral sclerosis.

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The rising role of cognitive reserve and associated compensatory brain networks in spinocerebellar ataxia type 2.
Siciliano L, Olivito G, Urbini N, Silveri MC, Leggio M. Siciliano L, et al. J Neurol. 2023 Oct;270(10):5071-5084. doi: 10.1007/s00415-023-11855-3. Epub 2023 Jul 8. J Neurol. 2023. PMID: 37421466 Free PMC article.
Age-Related Modifications of Electroencephalogram Coherence in Mice Models of Alzheimer's Disease and Amyotrophic Lateral Sclerosis.
Vorobyov V, Deev A, Chaprov K, Ustyugov AA, Lysikova E. Vorobyov V, et al. Biomedicines. 2023 Apr 11;11(4):1151. doi: 10.3390/biomedicines11041151. Biomedicines. 2023. PMID: 37189768 Free PMC article.
Cortico-muscular coherence in primary lateral sclerosis reveals abnormal cortical engagement during motor function beyond primary motor areas.
Bista S, Coffey A, Fasano A, Buxo T, Mitchell M, Giglia ER, Dukic S, Heverin M, Muthuraman M, Carson RG, Lowery M, Hardiman O, McManus L, Nasseroleslami B. Bista S, et al. Cereb Cortex. 2023 Jun 20;33(13):8712-8723. doi: 10.1093/cercor/bhad152. Cereb Cortex. 2023. PMID: 37143180 Free PMC article.
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Tahedl M, Tan EL, Chipika RH, Hengeveld JC, Vajda A, Doherty MA, McLaughlin RL, Siah WF, Hardiman O, Bede P. Tahedl M, et al. J Neurol. 2023 Jul;270(7):3511-3526. doi: 10.1007/s00415-023-11682-6. Epub 2023 Apr 6. J Neurol. 2023. PMID: 37022479 Free PMC article.

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References

1. Abidi M, de Marco G, Couillandre A, Feron M, Mseddi E, Termoz N, Querin G, Pradat PF, Bede P. Adaptive functional reorganization in amyotrophic lateral sclerosis: coexisting degenerative and compensatory changes. Eur J Neurol. 2020;27:121–128. - PubMed
1. Bede P, Iyer PM, Finegan E, Omer T, Hardiman O. Virtual brain biopsies in amyotrophic lateral sclerosis: Diagnostic classification based on in vivo pathological patterns. Neuroimage Clin. 2017;15:653–658. - PMC - PubMed
1. Bede P, Querin G, Pradat PF. The changing landscape of motor neuron disease imaging: the transition from descriptive studies to precision clinical tools. Curr Opin Neurol. 2018;31:431–438. - PubMed
1. Chipika RH, Finegan E, Li Hi Shing S, Hardiman O, Bede P. Tracking a fast-moving disease: longitudinal markers, monitoring, and clinical trial endpoints in ALS. Front Neurol. 2019;10:229. - PMC - PubMed
1. Christidi F, Karavasilis E, Riederer F, Zalonis I, Ferentinos P, Velonakis G, Xirou S, Rentzos M, Argiropoulos G, Zouvelou V, Zambelis T, Athanasakos A, Toulas P, Vadikolias K, Efstathopoulos E, Kollias S, Karandreas N, Kelekis N, Evdokimidis I. Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: A combined voxel-based morphometry and tract-based spatial statistics whole-brain analysis. Brain Imaging Behav. 2018;12:547–563. - PubMed

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[1] Abidi M, de Marco G, Couillandre A, Feron M, Mseddi E, Termoz N, Querin G, Pradat PF, Bede P. Adaptive functional reorganization in amyotrophic lateral sclerosis: coexisting degenerative and compensatory changes. Eur J Neurol. 2020;27:121–128. - PubMed

[2] Abidi M, de Marco G, Couillandre A, Feron M, Mseddi E, Termoz N, Querin G, Pradat PF, Bede P. Adaptive functional reorganization in amyotrophic lateral sclerosis: coexisting degenerative and compensatory changes. Eur J Neurol. 2020;27:121–128. - PubMed

[3] Bede P, Iyer PM, Finegan E, Omer T, Hardiman O. Virtual brain biopsies in amyotrophic lateral sclerosis: Diagnostic classification based on in vivo pathological patterns. Neuroimage Clin. 2017;15:653–658. - PMC - PubMed

[4] Bede P, Iyer PM, Finegan E, Omer T, Hardiman O. Virtual brain biopsies in amyotrophic lateral sclerosis: Diagnostic classification based on in vivo pathological patterns. Neuroimage Clin. 2017;15:653–658. - PMC - PubMed

[5] Bede P, Querin G, Pradat PF. The changing landscape of motor neuron disease imaging: the transition from descriptive studies to precision clinical tools. Curr Opin Neurol. 2018;31:431–438. - PubMed

[6] Bede P, Querin G, Pradat PF. The changing landscape of motor neuron disease imaging: the transition from descriptive studies to precision clinical tools. Curr Opin Neurol. 2018;31:431–438. - PubMed

[7] Chipika RH, Finegan E, Li Hi Shing S, Hardiman O, Bede P. Tracking a fast-moving disease: longitudinal markers, monitoring, and clinical trial endpoints in ALS. Front Neurol. 2019;10:229. - PMC - PubMed

[8] Chipika RH, Finegan E, Li Hi Shing S, Hardiman O, Bede P. Tracking a fast-moving disease: longitudinal markers, monitoring, and clinical trial endpoints in ALS. Front Neurol. 2019;10:229. - PMC - PubMed

[9] Christidi F, Karavasilis E, Riederer F, Zalonis I, Ferentinos P, Velonakis G, Xirou S, Rentzos M, Argiropoulos G, Zouvelou V, Zambelis T, Athanasakos A, Toulas P, Vadikolias K, Efstathopoulos E, Kollias S, Karandreas N, Kelekis N, Evdokimidis I. Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: A combined voxel-based morphometry and tract-based spatial statistics whole-brain analysis. Brain Imaging Behav. 2018;12:547–563. - PubMed

[10] Christidi F, Karavasilis E, Riederer F, Zalonis I, Ferentinos P, Velonakis G, Xirou S, Rentzos M, Argiropoulos G, Zouvelou V, Zambelis T, Athanasakos A, Toulas P, Vadikolias K, Efstathopoulos E, Kollias S, Karandreas N, Kelekis N, Evdokimidis I. Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: A combined voxel-based morphometry and tract-based spatial statistics whole-brain analysis. Brain Imaging Behav. 2018;12:547–563. - PubMed

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Degenerative and regenerative processes in amyotrophic lateral sclerosis: motor reserve, adaptation and putative compensatory changes

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Degenerative and regenerative processes in amyotrophic lateral sclerosis: motor reserve, adaptation and putative compensatory changes

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