Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection

Daniel Poston; Yiska Weisblum; Helen Wise; Kate Templeton; Sara Jenks; Theodora Hatziioannou; Paul Bieniasz

doi:10.1093/cid/ciaa1803

Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection

Clin Infect Dis. 2021 Sep 7;73(5):e1208-e1211. doi: 10.1093/cid/ciaa1803.

Authors

Daniel Poston^{1

2}, Yiska Weisblum¹, Helen Wise³, Kate Templeton³, Sara Jenks³, Theodora Hatziioannou¹, Paul Bieniasz^{1

4}

Affiliations

¹ Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
² Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.
³ Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, United Kingdom.
⁴ Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.

Abstract

Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.

Keywords: COVID-19; SARS-CoV-2; antibodies; neutralization; seasonal coronavirus.

Abstract

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