Absence of SARS-CoV-2 neutralizing activity in pre-pandemic sera from individuals with recent seasonal coronavirus infection

Clin Infect Dis. 2020 Dec 3;ciaa1803. doi: 10.1093/cid/ciaa1803. Online ahead of print.


Cross-reactive immune responses elicited by seasonal coronaviruses might impact SARS-CoV-2 susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in pre-pandemic sera from patients with prior PCR-confirmed seasonal coronavirus infection. While neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.

Keywords: COVID19; SARS-CoV-2; Seasonal coronavirus; antibodies; neutralization.