Connection between PD-L1 expression and standardized uptake value in NSCLC: an early prognostic treatment combination

Expert Rev Respir Med. 2021 May;15(5):675-679. doi: 10.1080/17476348.2021.1859373. Epub 2020 Dec 31.


Objectives: Lung cancer is still diagnosed at advanced stage and early treatment initiation is needed. Therefore, we need biomarkers or clusters of information that can provide early treatment prognosis.Methods: Biopsies were acquired from 471 patients-lung masses with CT-guided biopsy, convex probe transthorasic biopsy, and EBUS-TBNA convex probe with 18 G needles and 19 G needles.Results: Standardized uptake value (SUV) measurement is associated with female, smoking status, hepatic metastasis, adenocarcinoma and programmed death-ligand 1 (PD-L1). In specific we expect that SUV ≥ 7 is associated with PD-L1 ≥ 50.Conclusions: Lung masses indifferent of size that have SUV ≥ 7 will also have PD-L1 expression ≥ 50. Also, it is likely that these patients will be female with intense smoking habit and hepar or multiple metastasis.

Keywords: EBUS-TBNA; PET-CT; SUV; bronchoscopy; lung cancer.

MeSH terms

  • B7-H1 Antigen
  • Carcinoma, Non-Small-Cell Lung* / diagnostic imaging
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration
  • Female
  • Humans
  • Lung Neoplasms* / diagnostic imaging
  • Prognosis


  • B7-H1 Antigen
  • CD274 protein, human