Nutritional Control of Intestinal Stem Cells in Homeostasis and Tumorigenesis

Gizem Calibasi-Kocal; Omid Mashinchian; Yasemin Basbinar; Ender Ellidokuz; Chia-Wei Cheng; Ömer H Yilmaz

doi:10.1016/j.tem.2020.11.003

Nutritional Control of Intestinal Stem Cells in Homeostasis and Tumorigenesis

Trends Endocrinol Metab. 2021 Jan;32(1):20-35. doi: 10.1016/j.tem.2020.11.003. Epub 2020 Dec 1.

Authors

Gizem Calibasi-Kocal¹, Omid Mashinchian², Yasemin Basbinar³, Ender Ellidokuz⁴, Chia-Wei Cheng⁵, Ömer H Yilmaz⁶

Affiliations

¹ David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA; Department of Translational Oncology, Institute of Oncology, Dokuz Eylul University, Izmir, Turkey.
² Nestlé Research, Ecole Polytechnique Fédérale de Lausanne (EPFL) Innovation Park, Lausanne, Switzerland; School of Life Sciences, EPFL, Lausanne, Switzerland.
³ Department of Translational Oncology, Institute of Oncology, Dokuz Eylul University, Izmir, Turkey.
⁴ Department of Gastroenterology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
⁵ David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. Electronic address: cwcheng@mit.edu.
⁶ David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA; Department of Biology, MIT, Cambridge, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA; Departments of Pathology, Gastroenterology, and Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, USA. Electronic address: ohyilmaz@mit.edu.

PMID: 33277157
DOI: 10.1016/j.tem.2020.11.003

Abstract

Food and nutrition have a profound impact on organismal health and diseases, and tissue-specific adult stem cells play a crucial role in coordinating tissue maintenance by responding to dietary cues. Emerging evidence indicates that adult intestinal stem cells (ISCs) actively adjust their fate decisions in response to diets and nutritional states to drive intestinal adaptation. Here, we review the signaling mechanisms mediating the dietary responses imposed by caloric intake and nutritional composition (i.e., macronutrients and micronutrients), fasting-feeding patterns, diet-induced growth factors, and microbiota on ISCs and their relevance to the beginnings of intestinal tumors.

Keywords: colon cancer; diet; intestinal stem cell; microbiota.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Carcinogenesis
Colonic Neoplasms / metabolism
Homeostasis / physiology
Humans
Intestinal Mucosa / cytology
Intestinal Mucosa / metabolism
Intestines / cytology*
Stem Cells / cytology*
Stem Cells / metabolism*