Oncoplastic breast-conserving therapy and intraoperative radiotherapy for management of carcinoma in situ of the breast: A single-center experience

Breast J. 2020 Dec;26(12):2391-2394. doi: 10.1111/tbj.14093. Epub 2020 Dec 6.


Intraoperative radiation therapy (IORT) has been shown to reduce local recurrence rates among women with early-stage invasive ductal carcinoma, but data regarding its use among women with in situ carcinoma are limited. In this single-institution study, 50 women with in situ carcinoma were treated with oncoplastic breast-conserving surgery (OPS) and single-dose IORT. All 50 patients had "no tumor on ink," but 9 (16%) had margins < 2 mm and required additional therapy. No local recurrences were observed after a median follow-up of 46 months. Single-dose IORT is an efficacious treatment for well-selected patients with DCIS.

Keywords: ductal Carcinoma in situ; early Stage Breast cancer; intraoperative radiation therapy.

MeSH terms

  • Breast
  • Breast Neoplasms* / radiotherapy
  • Breast Neoplasms* / surgery
  • Carcinoma in Situ*
  • Carcinoma, Ductal, Breast* / surgery
  • Carcinoma, Intraductal, Noninfiltrating* / radiotherapy
  • Carcinoma, Intraductal, Noninfiltrating* / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Mastectomy, Segmental
  • Neoplasm Recurrence, Local / surgery
  • Radiotherapy, Adjuvant