Laminin-111 Improves the Anabolic Response to Mechanical Load in Aged Skeletal Muscle

J Gerontol A Biol Sci Med Sci. 2021 Mar 31;76(4):586-590. doi: 10.1093/gerona/glaa308.


Anabolic resistance to a mechanical stimulus may contribute to the loss of skeletal muscle mass observed with age. In this study, young and aged mice were injected with saline or human LM-111 (1 mg/kg). One week later, the myotendinous junction of the gastrocnemius muscle was removed via myotenectomy (MTE), thus placing a chronic mechanical stimulus on the remaining plantaris muscle for 2 weeks. LM-111 increased α7B integrin protein expression and clustering of the α7B integrin near DAPI+ nuclei in aged muscle in response to MTE. LM-111 reduced CD11b+ immune cells, enhanced repair, and improved the growth response to loading in aged plantaris muscle. These results suggest that LM-111 may represent a novel therapeutic approach to prevent and/or treat sarcopenia.

Keywords: Aging; Chronic mechanical loading; Extracellular matrix; Hypertrophy; Integrin.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / drug effects
  • Aging / physiology*
  • Anabolic Agents / pharmacology
  • Animals
  • Extracellular Matrix / physiology
  • Integrins / metabolism
  • Laminin / pharmacology*
  • Mice
  • Muscle, Skeletal* / metabolism
  • Muscle, Skeletal* / physiopathology
  • Physical Conditioning, Animal / physiology
  • Regeneration / drug effects
  • Sarcopenia* / metabolism
  • Sarcopenia* / prevention & control
  • Sarcopenia* / therapy


  • Anabolic Agents
  • Integrins
  • Laminin
  • integrin alpha7beta1