NCCN Guidelines Insights: Soft Tissue Sarcoma, Version 1.2021

J Natl Compr Canc Netw. 2020 Dec 2;18(12):1604-1612. doi: 10.6004/jnccn.2020.0058.


The NCCN Guidelines for Soft Tissue Sarcoma provide recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with soft tissue sarcomas. These NCCN Guidelines Insights summarize the panel discussion behind recent important updates to the guidelines, including the development of a separate and distinct guideline for gastrointestinal stromal tumors (GISTs); reconception of the management of desmoid tumors; inclusion of further recommendations for the diagnosis and management of extremity/body wall, head/neck sarcomas, and retroperitoneal sarcomas; modification and addition of systemic therapy regimens for sarcoma subtypes; and revision of the principles of radiation therapy for soft tissue sarcomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Extremities
  • Gastrointestinal Stromal Tumors
  • Humans
  • Practice Guidelines as Topic
  • Retroperitoneal Neoplasms
  • Sarcoma* / diagnosis
  • Sarcoma* / therapy
  • Soft Tissue Neoplasms* / diagnosis
  • Soft Tissue Neoplasms* / therapy