EMLA cream reduces the pain of venepuncture in children

Eur J Anaesthesiol. 1987 Nov;4(6):441-8.


EMLA cream (eutectic mixture of local anaesthetics) was tested in a double-blind clinical trial to examine its effect on the pain of venepuncture at induction of anaesthesia in 40 children (aged 3-13 yrs). Four pain-assessment methods were used and an assessment of the technical ease of venepuncture was made. EMLA was found to reduce significantly the pain and technical difficulty of venepuncture. This study confirms that EMLA is an effective method of reducing the pain and technical difficulty of paediatric venepuncture using 25-gauge needles for induction of anaesthesia in children.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Anesthesia, Intravenous*
  • Anesthetics, Local*
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Combinations / therapeutic use
  • Female
  • Humans
  • Lidocaine / therapeutic use*
  • Lidocaine, Prilocaine Drug Combination
  • Male
  • Pain / etiology*
  • Pain Measurement
  • Prilocaine / therapeutic use*
  • Punctures / adverse effects*


  • Anesthetics, Local
  • Drug Combinations
  • Lidocaine, Prilocaine Drug Combination
  • Prilocaine
  • Lidocaine