Vitamin C and Cardiovascular Disease: An Update

Antioxidants (Basel). 2020 Dec 3;9(12):1227. doi: 10.3390/antiox9121227.


The potential beneficial effects of the antioxidant properties of vitamin C have been investigated in a number of pathological conditions. In this review, we assess both clinical and preclinical studies evaluating the role of vitamin C in cardiac and vascular disorders, including coronary heart disease, heart failure, hypertension, and cerebrovascular diseases. Pitfalls and controversies in investigations on vitamin C and cardiovascular disorders are also discussed.

Keywords: COVID–19; GULO; SVCT; Vitamin C; ascorbic acid; blood pressure; coronavirus; dietary supplements; drug formulations; endothelial dysfunction; heart failure; hypertension; infections; liposomes; oxidative stress; stroke; vascular permeability.

Publication types

  • Review