Pyroptosis is a programmed death mode dependent on Caspase-1/4/5/11, which is caused by activation of inflammasome, accompanied by cell membrane rupture, pore formation and cell content release. As a new type of cell death, it is widely involved in respiratory diseases, such as pulmonary fibrosis, acute lung injury, bronchopulmonary dysplasia, chronic obstructive pulmonary disease and asthma. This article reviews the mechanism of pyroptosis and its role in different respiratory diseases, in order to provide new ideas for the treatment of respiratory diseases.
细胞焦亡是一种依赖半胱氨酸天冬氨酸蛋白酶（Caspase-1/4/5/11）的程序性死亡方式，主要特征是炎症小体激活，细胞膜破裂，形成孔洞，细胞内容物释放。细胞焦亡作为一种新型的细胞死亡方式广泛参与呼吸系统的疾病，如肺纤维化、急性肺损伤/呼吸窘迫综合征、支气管发育不良、慢性阻塞性肺疾病和哮喘等。本文综述细胞焦亡的发生机制以及在不同呼吸系统疾病中的作用，以期为呼吸系统疾病的治疗提供新思路。.
Keywords: Cell death; Inflammasomes; Pyroptosis; Respiratory diseases.