Diversity and dynamism in the cerebellum

doi:10.1038/s41593-020-00754-9

Review

. 2021 Feb;24(2):160-167.

doi: 10.1038/s41593-020-00754-9. Epub 2020 Dec 7.

Diversity and dynamism in the cerebellum

Chris I De Zeeuw^{1

2}, Stephen G Lisberger³, Jennifer L Raymond⁴

Affiliations

¹ Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
² Netherlands Institute for Neuroscience, Royal Academy of Sciences (KNAW), Amsterdam, The Netherlands.
³ Department of Neurobiology, Duke University, Durham, NC, USA. lisberger@neuro.duke.edu.
⁴ Department of Neurobiology, Stanford University, Stanford, CA, USA.

PMID: 33288911
DOI: 10.1038/s41593-020-00754-9

Review

Diversity and dynamism in the cerebellum

Chris I De Zeeuw et al. Nat Neurosci. 2021 Feb.

. 2021 Feb;24(2):160-167.

doi: 10.1038/s41593-020-00754-9. Epub 2020 Dec 7.

Authors

Chris I De Zeeuw^{1

2}, Stephen G Lisberger³, Jennifer L Raymond⁴

Affiliations

¹ Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
² Netherlands Institute for Neuroscience, Royal Academy of Sciences (KNAW), Amsterdam, The Netherlands.
³ Department of Neurobiology, Duke University, Durham, NC, USA. lisberger@neuro.duke.edu.
⁴ Department of Neurobiology, Stanford University, Stanford, CA, USA.

PMID: 33288911
DOI: 10.1038/s41593-020-00754-9

Erratum in

Publisher Correction: Diversity and dynamism in the cerebellum.
De Zeeuw CI, Lisberger SG, Raymond JL. De Zeeuw CI, et al. Nat Neurosci. 2021 Mar;24(3):450. doi: 10.1038/s41593-020-00782-5. Nat Neurosci. 2021. PMID: 33398139 No abstract available.

Abstract

The past several years have brought revelations and paradigm shifts in research on the cerebellum. Historically viewed as a simple sensorimotor controller with homogeneous architecture, the cerebellum is increasingly implicated in cognitive functions. It possesses an impressive diversity of molecular, cellular and circuit mechanisms, embedded in a dynamic, recurrent circuit architecture. Recent insights about the diversity and dynamism of the cerebellum provide a roadmap for the next decade of cerebellar research, challenging some old concepts, reinvigorating others and defining major new research directions.

PubMed Disclaimer

Cited by

Optogenetic activation of mGluR1 signaling in the cerebellum induces synaptic plasticity.
Surdin T, Preissing B, Rohr L, Grömmke M, Böke H, Barcik M, Azimi Z, Jancke D, Herlitze S, Mark MD, Siveke I. Surdin T, et al. iScience. 2022 Dec 17;26(1):105828. doi: 10.1016/j.isci.2022.105828. eCollection 2023 Jan 20. iScience. 2022. PMID: 36632066 Free PMC article.
Learning temporal relationships between symbols with Laplace Neural Manifolds.
Howard MW, Esfahani ZG, Le B, Sederberg PB. Howard MW, et al. ArXiv [Preprint]. 2024 Sep 22:arXiv:2302.10163v4. ArXiv. 2024. PMID: 36866224 Free PMC article. Preprint.
Editorial: Physiology and pathology of neuroglia.
Reyes-Haro D, López-Juárez A, Rodríguez-Contreras A. Reyes-Haro D, et al. Front Cell Neurosci. 2023 Jul 18;17:1246885. doi: 10.3389/fncel.2023.1246885. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37534041 Free PMC article. No abstract available.
Interactions between circuit architecture and plasticity in a closed-loop cerebellar system.
Payne HL, Raymond JL, Goldman MS. Payne HL, et al. Elife. 2024 Mar 7;13:e84770. doi: 10.7554/eLife.84770. Elife. 2024. PMID: 38451856 Free PMC article.
Synaptic variance and action potential firing of cerebellar output neurons during motor learning in larval zebrafish.
Najac M, McLean DL, Raman IM. Najac M, et al. Curr Biol. 2023 Aug 21;33(16):3299-3311.e3. doi: 10.1016/j.cub.2023.06.045. Epub 2023 Jul 7. Curr Biol. 2023. PMID: 37421952 Free PMC article.

See all "Cited by" articles

References

1. Witter, L., Rudolph, S., Pressler, R. T., Lahlaf, S. I. & Regehr, W. G. Purkinje cell collaterals enable output signals from the cerebellar cortex to feed back to Purkinje cells and interneurons. Neuron 91, 312–319 (2016). - PubMed - PMC - DOI
1. Rieubland, S., Roth, A. & Häusser, M. Structured connectivity in cerebellar inhibitory networks. Neuron 81, 913–929 (2014). - PubMed - PMC - DOI
1. Arlt, C. & Häusser, M. Microcircuit rules governing impact of single interneurons on Purkinje cell output in vivo. Cell Rep. 30, 3020–3035.e3 (2020). - PubMed - PMC - DOI
1. Hull, C. & Regehr, W. G. Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. Neuron 73, 149–158 (2012). - PubMed - PMC - DOI
1. Mann-Metzer, P. & Yarom, Y. Electrotonic coupling interacts with intrinsic properties to generate synchronized activity in cerebellar networks of inhibitory interneurons. J. Neurosci. 19, 3298–3306 (1999). - PubMed - PMC - DOI

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
Miscellaneous
- NCI CPTAC Assay Portal

[1] Witter, L., Rudolph, S., Pressler, R. T., Lahlaf, S. I. & Regehr, W. G. Purkinje cell collaterals enable output signals from the cerebellar cortex to feed back to Purkinje cells and interneurons. Neuron 91, 312–319 (2016). - PubMed - PMC - DOI

[2] Witter, L., Rudolph, S., Pressler, R. T., Lahlaf, S. I. & Regehr, W. G. Purkinje cell collaterals enable output signals from the cerebellar cortex to feed back to Purkinje cells and interneurons. Neuron 91, 312–319 (2016). - PubMed - PMC - DOI

[3] Rieubland, S., Roth, A. & Häusser, M. Structured connectivity in cerebellar inhibitory networks. Neuron 81, 913–929 (2014). - PubMed - PMC - DOI

[4] Rieubland, S., Roth, A. & Häusser, M. Structured connectivity in cerebellar inhibitory networks. Neuron 81, 913–929 (2014). - PubMed - PMC - DOI

[5] Arlt, C. & Häusser, M. Microcircuit rules governing impact of single interneurons on Purkinje cell output in vivo. Cell Rep. 30, 3020–3035.e3 (2020). - PubMed - PMC - DOI

[6] Arlt, C. & Häusser, M. Microcircuit rules governing impact of single interneurons on Purkinje cell output in vivo. Cell Rep. 30, 3020–3035.e3 (2020). - PubMed - PMC - DOI

[7] Hull, C. & Regehr, W. G. Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. Neuron 73, 149–158 (2012). - PubMed - PMC - DOI

[8] Hull, C. & Regehr, W. G. Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. Neuron 73, 149–158 (2012). - PubMed - PMC - DOI

[9] Mann-Metzer, P. & Yarom, Y. Electrotonic coupling interacts with intrinsic properties to generate synchronized activity in cerebellar networks of inhibitory interneurons. J. Neurosci. 19, 3298–3306 (1999). - PubMed - PMC - DOI

[10] Mann-Metzer, P. & Yarom, Y. Electrotonic coupling interacts with intrinsic properties to generate synchronized activity in cerebellar networks of inhibitory interneurons. J. Neurosci. 19, 3298–3306 (1999). - PubMed - PMC - DOI

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Diversity and dynamism in the cerebellum

Affiliations

Diversity and dynamism in the cerebellum

Authors

Affiliations

Erratum in

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Miscellaneous