Serological tests for COVID-19: Potential opportunities

Cell Biol Int. 2021 Apr;45(4):740-748. doi: 10.1002/cbin.11516. Epub 2021 Jan 13.


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel betacoronavirus, caused a pandemic leading to a standstill of nearly all global activities. There are some controversies on the production of specific immunoglobulin M (IgM) and IgG antibodies after the infection with SARS-CoV-2. This paper seeks to elaborate on the potential application of IgM and IgG antibodies and the viral antigens for the diagnosis and the course of the disease as well as the recurrence of positive nucleic acid tests after discharge.

Keywords: IgG; IgM; SARS-CoV-2; antibody; coronavirus; diagnosis.

Publication types

  • Review

MeSH terms

  • Antibodies, Viral / blood*
  • Antigens, Viral / immunology
  • COVID-19 / immunology
  • COVID-19 / pathology*
  • COVID-19 / virology
  • COVID-19 Vaccines / immunology
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • SARS-CoV-2 / immunology*
  • SARS-CoV-2 / isolation & purification
  • SARS-CoV-2 / metabolism
  • Serologic Tests


  • Antibodies, Viral
  • Antigens, Viral
  • COVID-19 Vaccines
  • Immunoglobulin G
  • Immunoglobulin M