A short history of guide RNAs: The intricate path that led to the discovery of a basic biological concept

EMBO Rep. 2020 Dec 3;21(12):e51918. doi: 10.15252/embr.202051918. Epub 2020 Dec 1.


This year's Nobel prize for the CRISPR/Cas system is an illustrative example of how scientific breakthroughs rests on preceding work: the discovery of guide RNAs in the 1990s.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • History, 20th Century
  • Homeostasis
  • Nobel Prize*
  • RNA, Guide, Kinetoplastida* / genetics


  • RNA, Guide