Dynamic Changes of Mitochondrial DNA Copy Number in Gastrointestinal Tract Cancers: A Systematic Review and Meta-Analysis

Cancer Invest. 2021 Feb;39(2):163-179. doi: 10.1080/07357907.2020.1857394. Epub 2021 Jan 11.

Abstract

We have performed a systematic review and meta-analysis for evaluation of mitochondrial DNA copy number (mtDNA-CN) alterations in peripheral blood leukocytes (PBL), and tumor tissues of gastrointestinal tract (GIT) cancers. Analysis of the PBL demonstrated a significant decrease [OR: 0.6 (0.5, 0.8)] and increase [OR: 1.4 (1.1, 1.9)] prior to and following GIT cancer development, respectively. This trend was more evident in CRC, and GC subgroups. Analysis of tissue yielded high levels of heterogeneity. However, the mean difference for the CRC subgroup was statistically significant [1.5 (1.0, 2.2)]. Our analysis suggests mtDNA-CN deserves further investigations as a GIT-cancer screening tool.

Keywords: PBL; gastrointestinal tract cancers; mtDNA copy number; systematic review and meta-analysis; tumor.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • DNA Copy Number Variations*
  • DNA, Mitochondrial / genetics
  • Early Detection of Cancer
  • Gastrointestinal Neoplasms / diagnosis*
  • Gastrointestinal Neoplasms / genetics
  • Genetic Predisposition to Disease
  • Humans
  • Leukocytes, Mononuclear / chemistry
  • Mitochondria / genetics*

Substances

  • DNA, Mitochondrial